Br J Surg 2013;100(7):863 72

We also used multivariable mixed Poisson regression to examine factors associated with new records of challenging behaviour and new prescription of antipsychotic drugs in people without a history at cohort entry. We investigated multiplicative interactions between sex, challenging behaviour, and prescription of antipsychotics as a pre specified hypothesis by including the appropriate interaction terms in the regression model. In the regression model examining new prescriptions of antipsychotics, we tested the influence of excluding sleep codes from the challenging behaviour code list as a sensitivity analysis.

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